News briefs

In the news

One endgame would be getting 80 to 90% vaccination and/or previously infected. That's the endgame. And vaccination is so much better than having infection, because some people will die from infection.”
Stanley Perlman, MD, PhD

Stanley Perlman, MD, PhD, a coronavirus expert and UI professor of microbiology and immunology, tells Business Insider in a story about managing expectations for what’s ahead in the COVID-19 pandemic.  

Really what we're seeing is that patients of all walks of life, all ages, all types of comorbidities, from completely healthy to people with chronic illness, they're all presenting with various degrees of this.”
Alejandro Pezzulo, MD

Alejandro Pezzulo, MD, a member of the UI Post-COVID-19 Clinic, tells Iowa Public Radio about resources for COVID-19 “long haulers,” or those who are experiencing long-term symptoms of COVID-19 such as fatigue and brain fog. The UI clinic has seen hundreds of patients from across the state since opening in summer 2020. 

In science we have learned that everything is a Goldilocks system.”
Ashutosh Mangalam, PhD

Ashutosh Mangalam, PhD, UI associate professor of pathology, describes to Inverse magazine his study showing a diet rich in isoflavone protects against multiple sclerosis (MS)-like symptoms in a mouse model. But for those who are worried about MS, he says there is no reason to start eating a bean-rich diet just yet and that everything is good in moderation. 

Paper trail

Sishc BJ, Ding L, Nam TK, Heer CDRodman SNSchoenfeld JDFath MA, Saha D, Pulliam CF, Langen B, Beardsley RA, Riley DP, Keene JL, Spitz DR, Story MD. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Sci Transl Med. 2021 May 12;13(593):eabb3768. doi: 10.1126/scitranslmed.abb3768.  

Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS Jr, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG; Overcoming COVID-19 Investigators. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 Mar 16;325(11):1074-1087. doi: 10.1001/jama.2021.2091.  

Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D, Crenshaw DL, Effron MB, Re RN, Gupta K, Anderson RD, Pepine CJ, Handberg EM, Manning BR, Jain SK, Girotra S, Riley D, DeWalt DA, Whittle J, Goldberg YH, Roger VL, Hess R, Benziger CP, Farrehi P, Zhou L, Ford DE, Haynes K, VanWormer JJ, Knowlton KU, Kraschnewski JL, Polonsky TS, Fintel DJ, Ahmad FS, McClay JC, Campbell JR, Bell DS, Fonarow GC, Bradley SM, Paranjape A, Roe MT, Robertson HR, Curtis LH, Sharlow AG, Berdan LG, Hammill BG, Harris DF, Qualls LG, Marquis-Gravel G, Modrow MF, Marcus GM, Carton TW, Nauman E, Waitman LR, Kho AN, Shenkman EA, McTigue KM, Kaushal R, Masoudi FA, Antman EM, Davidson DR, Edgley K, Merritt JG, Brown LS, Zemon DN, McCormick TE 3rd, Alikhaani JD, Gregoire KC, Rothman RL, Harrington RA, Hernandez AF; ADAPTABLE Team. Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. N Engl J Med. 2021 May 27;384(21):1981-1990. doi: 10.1056/NEJMoa2102137.  

White DS, Chowdhury S, Idikuda V, Zhang R, Retterer ST, Goldsmith RH, Chanda B. cAMP binding to closed pacemaker ion channels is non-cooperativeNature. 2021 Jul;595(7868):606-610. doi: 10.1038/s41586-021-03686-x.